The agency has evaluated the potential risks associated with methyl eugenol and has determined, that there is a reasonable certainty that no harm to any population subgroup will result from dietary and water exposure to methyl eugenol from uses specified in the existing exemption for the requirement for tolerance for methyl eugenol under 40 cfr. Biopesticides fact sheet for methyl eugenol me author. Methyl eugenol, however, poses no risks that require mitigation. Methyl eugenol is produced by the methylation of eugenol 8. The annual production of methyleugenol in the united states of america in 1990 was estimated at 11. Easytohandle fruit fly lure plugs university of hawaii. Kinetics data in rats are consistent with a rapid clearance from the blood, metabolism in the liver mediated by the p450 system, and excretion in the urine. Information available in 2010 indicated that methyleugenol was manufactured by 19 companies in the usa, four companies in the peoples republic of china, two companies each in germany and china. View of synergistic and inhibitory interactions between methyl. Material safety data sheet sect ion 1 methyl eugenol 1 chemical product and company identification msds name. Methyl eugenol is present in the essential oils of several plant species.
Its occurrence, distribution, and role in nature, especially in relation to insect behavior and pollination. Synthesis of methyl eugenol from crude cloves leaf oil. Many reports have shown that methyl eugenol is not among the major compounds of clove oil, its presence in clove oil is very small or even only in trace amounts eugenol, eugenol. The comment period is intended to provide an opportunity for public input and a mechanism for initiating any necessary amendments to the. Methyl eugenol allylveratrol is a natural chemical compound classified as a phenylpropene, a type of phenylpropanoid. Human cytochrome p450 enzymes of importance for the bioactivation of methyleugenol to the proximate carcinogen 1hydroxymethyleugenol. Based on the lower end of the noel and applying a times safety factor for systemic effects a daily dose for methyl eugenol of 60. In a subset of serum samples from adults participating in the third national health and nutrition examination. Human cytochrome p450 enzymes of importance for the. Methyleugenol is produced by the methylation of eugenol burdock. The agency therefore is issuing the methyl eugenol tred, its risk assessments, and related support documents simultaneously for public comment. Many reports have shown that methyl eugenol is not among the major compounds of clove oil, its presence in clove oil is very small or even only in trace amounts eugenol. Article details synergistic and inhibitory interactions between methyl eugenol. To supplement previous experiments with methyl eugenol and.
Pandey many of the bactrocera fruit fl y males are attracted either to methyl eugenol or to cuelure. Gray, which contain a methyl eugenollike compound nishida et al. Observed effect level for methyl eugenol in the rat in the doserange of 110 mgkg body weightday. Methyl eugenol is used as a fragrance in perfumes 0. The environmental monitoring of methyl eugenol, naled and. Methyl eugenol is used in commercial products as a flavorant at concentrations of 5 to 52 ppm and in fragrances at concentrations of 0. Following administration of a single oral dose of methyleugenol. Methyleugenol is produced by the methylation of eugenol burdock, 2005. It is the methyl ether of eugenol and is important to insect behavior and pollination. Abstract methyl eugenol me and cuelure cl traps with solid lure dispensers were deployed in areas with low and high populations of oriental fruit. Methyl eugenol is a component of several essential oils that are sold for use in aromatherapy, massage oils and alternative medicines 7.
Methyl eugenol 93152 100 eugenol methyl ether 4allyl1,2dimethoxybenzene solid polymeric matrix na na na section 4. Methyl eugenol can be found naturally in many kinds of spices such as clove oil, nutmeg, etc. It is rapidly absorbed following oral administration to rats and mice. Of the four invasive pest fruit fl ies established in hawaii, oriental fruit fl y males are attracted to methyl eugenol whereas the melon fl y males are attracted to cuelure. The presence of methyleugenol in essential oils and aromatic plants can be determined by gas. Biopesticides fact sheet for methyl eugenol me keywords. Methyleugenol some chemicals present in industrial and. Chemical structures of methyl eugenol me and its analogs.
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